What is Berberine? Berberine is a bioactive compound found in several plants, including Berberis vulgaris (barberry), Coptis chinensis (goldenthread), and Hydrastis canadensis (goldenseal). It belongs to a class of compounds known as alkaloids and is recognized for its distinctive yellow color. Berberine has been used in traditional medicine for centuries, particularly in Chinese and Ayurvedic medicine, for its wide-ranging health benefits. Historical